Are you Looking to Buy Daraprim (Pyrimethamine) from PrescriptionPoint.

Daraprim (pyrimethamine)

Indications

• Daraprim tablets are prescribed for:
• Treating toxoplasmosis, an infection caused by the Toxoplasma gondii parasite
• Preventing and treating malaria when used in combination with other medications
• Managing certain parasitic infections, particularly in immunocompromised patients such as those with HIV/AIDS

Dosage and Administration

• Take Daraprim exactly as prescribed by your doctor.
• Swallow the tablets whole with a full glass of water.
• Take medication with food to minimize stomach upset.
• Follow your doctor’s instructions regarding the timing and frequency of doses, which may vary depending on the condition being treated.
• Do not crush or chew the tablets.
• Do not take more than the prescribed dose without consulting your doctor.
• Avoid skipping doses; if you miss a dose, take it as soon as you remember unless it is almost time for your next dose.

Mechanism of Action

Pyrimethamine, the active ingredient in Daraprim, works by inhibiting the enzyme dihydrofolate reductase in parasites, which is crucial for the synthesis of nucleic acids. This inhibition impedes the growth and replication of the parasites, effectively controlling the infection.

Contraindications

• Daraprim tablets should not be used if you have:
• Allergy to pyrimethamine or any other ingredients in the tablets
• Severe liver disease
• Severe renal impairment unless closely monitored by a doctor
• Anemia or other blood disorders unless under medical supervision

Side Effects

Common side effects:

• Nausea
• Vomiting
• Loss of appetite
• Headache
• Insomnia

Serious side effects:

• Severe allergic reactions (e.g., rash, itching, swelling, severe dizziness, difficulty breathing)
• Signs of bone marrow suppression (e.g., unusual tiredness, easy bruising or bleeding, persistent sore throat or fever)
• Liver problems (e.g., yellowing of the skin or eyes, dark urine, persistent nausea or vomiting)
• Severe skin reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis)

Precautions

• Inform your doctor about any other medications or supplements you are taking before starting Daraprim.
• Discuss your complete medical history with your doctor, especially if you have liver disease, kidney disease, or a history of blood disorders.
• Regular blood tests may be necessary to monitor your response to the medication and check for side effects.
• If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using Daraprim.
• Use effective contraception to prevent pregnancy while taking Daraprim and for a specified period after completing the treatment, as advised by your doctor.

Storage Instructions

• Store Daraprim tablets at room temperature away from moisture and heat.
• Keep the bottle tightly closed when not in use.
• Keep out of reach of children.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/08578slr016_daraprim_lbl.pdf