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Dantrium (dantrolene sodium)

Indications

Dantrium capsules are prescribed for:

• Treating muscle spasticity (stiffness and spasms) associated with conditions like multiple sclerosis, cerebral palsy, and spinal cord injuries
• Managing malignant hyperthermia, a severe reaction to certain drugs used during surgery
• Reducing muscle stiffness and spasms caused by stroke or other brain injuries

Dosage and Administration

• Take Dantrium exactly as prescribed by your doctor.
• Swallow the capsules whole with a full glass of water.
• Take the medication at the same time each day to maintain an even level in your body.
• Follow your doctor’s instructions regarding the timing and frequency of doses.
• Do not crush or chew the capsules.
• Do not take more than the prescribed dose without consulting your doctor.
• Avoid skipping doses; if you miss a dose, take it as soon as you remember unless it is almost time for your next dose.

Mechanism of Action

Dantrolene sodium, the active ingredient in Dantrium capsules, works by interfering with the release of calcium in the muscles, which helps to relax them. This action reduces muscle spasticity and stiffness, making it easier for patients to move.

Contraindications

• Dantrium capsules should not be used if you have:
• Allergy to dantrolene sodium or any other ingredients in the capsules
• Active liver disease or significantly impaired liver function
• Severe heart problems, such as advanced heart failure
• Conditions that contraindicate the use of muscle relaxants

Side Effects

Common side effects:

• Drowsiness
• Dizziness
• Weakness
• Fatigue
• Diarrhea

Serious side effects:

• Liver problems (e.g., yellowing of the skin or eyes, dark urine, persistent nausea or vomiting)
• Severe allergic reactions (e.g., rash, itching, swelling, severe dizziness, difficulty breathing)
• Muscle weakness affecting swallowing, speaking, or breathing
• Changes in mental or mood state (e.g., confusion, depression)

Precautions

• Inform your doctor about any other medications or supplements you are taking before starting Dantrium.
• Discuss your complete medical history with your doctor, especially if you have liver disease, heart disease, or a history of respiratory issues.
• Avoid activities that require full alertness, such as driving or operating machinery, until you know how Dantrium affects you.
• If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using Dantrium.

Storage Instructions

• Store Dantrium capsules at room temperature away from moisture and heat.
• Keep the bottle tightly closed when not in use.
• Keep out of reach of children.

References

https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2012/017443Orig1s043,s046,s048,s049ltr.pdf