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Comtan (entacapone)

Indications

• Comtan tablets are indicated for the treatment of Parkinson’s disease as an adjunct to levodopa/carbidopa therapy.
• It helps to enhance the effectiveness of levodopa/carbidopa by prolonging its duration of action.

Dosage and Administration

• Take Comtan tablets exactly as prescribed by your doctor, usually one tablet with each dose of levodopa/carbidopa, up to eight times a day.
• Swallow the tablets whole with a full glass of water.
• Take Comtan with or without food as directed by your doctor.
• Maintain a consistent schedule with your levodopa/carbidopa doses to achieve the best therapeutic effect.
• Do not exceed the prescribed dose of Comtan or use it more frequently than directed by your doctor.
• Avoid stopping Comtan abruptly without consulting your doctor, as it may worsen your symptoms.
• Do not share your medication with others, even if they have similar symptoms.

Mechanism of Action

Comtan contains Entacapone, a catechol-O-methyltransferase (COMT) inhibitor. It works by inhibiting the COMT enzyme, which breaks down levodopa in the body. This action increases the levels and prolongs the effect of levodopa in the brain, improving the control of Parkinson’s symptoms.

Contraindications

• Do not use Comtan if you have a known allergy to Entacapone or any other ingredients in the tablets.
• Avoid Comtan if you have a history of severe liver disease.
• Consult your doctor before using Comtan if you have existing medical conditions, particularly liver dysfunction or rhabdomyolysis.

Side Effects

Common Side Effects:

• Nausea
• Diarrhea
• Abdominal pain
• Dry mouth
• Dizziness
• Fatigue

Serious Side Effects:

• Severe diarrhea or persistent abdominal pain
• Unexplained muscle pain, tenderness, or weakness
• Signs of liver problems (yellowing of the skin or eyes, dark urine, severe fatigue)
• Hallucinations or confusion
• Severe allergic reactions (rash, itching, swelling, difficulty breathing)

Precautions

• Inform your doctor about any existing medical conditions or medications you are taking before using Comtan.
• Be cautious if you have a history of liver problems, as liver function tests may be required.
• Monitor for signs of rhabdomyolysis, such as muscle pain, tenderness, or weakness, and report these symptoms to your doctor immediately.
• If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Comtan with your healthcare provider.

Storage Instructions

• Store Comtan tablets at room temperature (20°C to 25°C) in a dry place, away from moisture and heat.
• Keep the tablets in their original packaging until they are ready to use.
• Do not use Comtan if the tablets appear discolored, damaged, or show signs of deterioration.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020796s016lbl.pdf