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Arimidex (anastrozole)

Indications

• Specifically indicated for hormone receptor-positive early breast cancer, helping reduce the risk of recurrence.
• For postmenopausal women whose cancer has spread, Arimidex is used as an initial treatment.
• Employed in advanced breast cancer that has progressed following tamoxifen therapy.

Dosage and Administration

• Take one tablet daily, preferably at the same time each day.
• Swallow the tablet whole with water, with or without food.
• Take the missed dose as soon as you remember, unless it is almost time for the next one.
• Stick to the dosing schedule provided by your healthcare provider.
• Do not chew, crush, or split the tablet.
• Do not double up the next dose if a dose is missed.
• Do not take Arimidex with estrogen-containing therapies as they can interfere with its action.

Mechanism of Action

Arimidex (anastrozole) works by inhibiting the enzyme aromatase, which is involved in estrogen production. By lowering estrogen levels in the body, Arimidex helps slow the growth of estrogen-dependent breast cancer cells.

Contraindications

• Allergy to Anastrozole: Do not use it if you are allergic to Anastrozole or any ingredients in Arimidex.
• Pregnancy: Not for use in pregnant women due to potential harm to the fetus.
• Breastfeeding: Do not use the medication while breastfeeding as it may affect the baby.
• Premenopausal Women: Not indicated for women who have not yet gone through menopause.
• Severe Liver Disease: Avoid use in patients with severe liver impairment.

Side Effects

Common Side Effects:

• Headache
• Nausea
• Hot flashes
• Weakness
• Joint pain or stiffness
• High blood pressure

Serious Side Effects:

• Severe allergic reactions (rash, itching, swelling)
• Chest pain or discomfort
• Shortness of breath
• Severe bone pain
• Liver problems (yellowing of the skin or eyes, dark urine)

Precautions

• Bone Health: Monitor bone density as Arimidex can cause bone thinning.
• Heart Health: Regularly check heart function, especially in those with pre-existing heart conditions.
• Cholesterol Levels: Monitor blood cholesterol levels as Arimidex can increase cholesterol.
• Liver Function: Regular liver function tests are recommended.
• Renal Function: Caution in patients with moderate to severe kidney impairment.
• Driving and Operating Machinery: Be cautious as the medication may cause dizziness or fatigue.

Storage Instructions

• Store at room temperature, between 20°C to 25°C (68°F to 77°F).
• Store in a dry place, away from moisture and heat.
• Keep the tablets in their original container, tightly closed.
• Keep out of reach of children to prevent accidental ingestion.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020541s026lbl.pdf