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Seasonale (ethinyl estradiol and levonorgestrel) 

Indications 

Seasonale is used for the prevention of pregnancy. It is an extended-cycle oral contraceptive that allows for fewer menstrual periods each year. 

Dosage and Administration 

• Take Seasonale exactly as prescribed by your doctor. 
• Swallow the tablets whole with a full glass of water. 
• Take one tablet at the same time every day to maintain consistent hormone levels in your bloodstream. 
• Follow the pill pack sequence: 84 active tablets followed by 7 inactive (placebo) tablets. 
• Start a new pack immediately after finishing the previous one to maintain contraceptive effectiveness. 
• Inform your doctor of all medications, supplements, and herbal products you are currently taking. 
• Do not crush, chew, or break the tablets, as this can affect the drug’s effectiveness. 
• Avoid skipping doses; take Seasonale consistently as prescribed to maintain its effectiveness. 
• Do not take more than the prescribed dose to prevent potential side effects or overdose. 
• Avoid smoking while taking Seasonale, as it increases the risk of serious cardiovascular side effects. 
• Do not stop taking Seasonale without consulting your doctor, even if you experience side effects. 

Mechanism of Action 

Seasonale works by inhibiting ovulation, altering the cervical mucus to prevent sperm penetration, and changing the uterine lining to prevent attachment of a fertilized egg. These actions help to prevent pregnancy. 

Contraindications 

• Do not use if you are allergic to ethinyl estradiol, levonorgestrel, or any ingredients in Seasonale. 
• Avoid use if you have a history of blood clots, stroke, or heart attack. 
• Not recommended for individuals with certain types of cancers, especially those influenced by hormones (breast or uterine cancer). 
• Consult your doctor if you have a history of liver disease, uncontrolled high blood pressure, or severe migraines before taking this medication. 
• Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. 

Side Effects 

Common Side Effects 

• Nausea 
• Vomiting 
• Headache 
• Breast tenderness 
• Weight gain 
• Mood changes 
• Irregular bleeding or spotting 

Serious Side Effects 

• Severe allergic reactions (rash, itching, swelling of the face/tongue/throat) 
• Signs of blood clots (pain/swelling in the leg, sudden chest pain, difficulty breathing) 
• Severe headache or migraine 
• Vision changes or eye pain 
• Yellowing of the skin or eyes (jaundice) 
• Unusual bleeding or bruising 
• Signs of a stroke (sudden numbness, confusion, difficulty speaking) 

Precautions 

• Inform your doctor of any existing health conditions, especially heart disease, liver disease, blood clotting disorders, or migraines. 
• Regularly monitor for any side effects and report any severe or unusual symptoms to your healthcare provider. 
• Avoid activities that increase the risk of injury or bleeding. 
• Take Seasonale consistently to maintain its effectiveness in preventing pregnancy. 
• Discuss all medications, supplements, and herbal products you are taking with your healthcare provider to avoid interactions. 
• Inform your healthcare provider if you need to stop Seasonale temporarily for surgery or dental procedures. 

Storage Instructions 

• Store Seasonale tablets at room temperature between 68°F and 77°F (20°C and 25°C). 
• Keep the medication in its original container, tightly closed, and away from moisture and light. 
• Do not store it in the bathroom to avoid exposure to humidity. 
• Keep out of reach of children and pets.

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021544s009s010lbl.pdf