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Formulation : Extended Release Tablet
Drug Name Dosage Quantity Price Buy Now
Janumet XR 50/1000mg 56 $105.00 Add To Cart
Janumet XR 50/500mg 60 $124.90 Add To Cart
Janumet XR 50/1000mg 112 $190.00 Add To Cart
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Janumet XR 50/1000mg 168 $283.25 Add To Cart
Janumet XR 50/500mg 180 $339.20 Add To Cart
Janumet XR 100/1000mg 28 $101.00 Add To Cart
Janumet XR 100/1000mg 84 $293.00 Add To Cart
Janumet XR
Dosage: 50/1000mg
Quantity: 56
Price: $105.00
Janumet XR
Dosage: 50/500mg
Quantity: 60
Price: $124.90
Janumet XR
Dosage: 50/1000mg
Quantity: 112
Price: $190.00
Janumet XR
Dosage: 50/500mg
Quantity: 120
Price: $230.20
Janumet XR
Dosage: 50/1000mg
Quantity: 168
Price: $283.25
Janumet XR
Dosage: 50/500mg
Quantity: 180
Price: $339.20
Janumet XR
Dosage: 100/1000mg
Quantity: 28
Price: $101.00
Janumet XR
Dosage: 100/1000mg
Quantity: 84
Price: $293.00

What is Janumet XR?

Janumet XR is a brand-name medication containing two antidiabetic medications to improve blood sugar control in adults with type 2 diabetes mellitus: metformin hydrochloride extended-release, belonging to the biguanide class, and sitagliptin, a dipeptidyl peptidase-4 (DPP4) inhibitor.  

This medication should be used along with a proper diet and regular exercise.

This medication requires a doctor’s prescription upon obtaining it.

Janumet dosage

Janumet XR comes in as an extended-release tablet with three different strengths: 50/500 mg, 50/1000 mg, and 100/1000 mg.

The dose of this medication should be individualized and based on the patient’s present treatment, tolerability, and effectiveness, while not going above the maximum daily dose of 100 mg sitagliptin and 2000 mg metformin.

The recommended daily dose of Janumet XR in patients not currently on metformin treatment is 100 mg sitagliptin and 1000 mg metformin hydrochloride extended-release. If this dose of metformin provides inadequate glycemic control, the dose can be gradually titrated up to the maximum recommended daily dose.

The recommended daily dose of Janumet XR in patients already on Metformin treatment is 100 mg sitagliptin and the dose of metformin was previously prescribed to them.


Take Janumet XR exactly as prescribed by your physician. Read all the medication guides and instruction sheets and carefully follow all the instructions on the prescription label.

This medication should be taken with food to lower gastrointestinal side effects associated with its metformin content. Preferably, this medication should be taken once daily with a meal in the evening.

This drug should be swallowed whole. Crushing, splitting, or chewing the tablet is not recommended.

You may experience low blood sugar (hypoglycemia) and feel dizzy, hungry, shaky, or confused. This can be treated quickly by eating or drinking fast-acting sources of sugar such as hard candy, fruit juice, crackers, and non-diet soda.

Watch out for increased blood sugar (hyperglycemia), such as increased thirst and urination. Blood tests will be needed often.


Do not take Janumet XR if you are allergic to it or to any of its active and inactive components or if you have severe kidney disease or diabetic ketoacidosis.  

Before taking this medication, you must inform your doctor about your medical history, especially heart failure, kidney problems, liver problems, pancreatitis, gallstones, high triglycerides, and alcoholism.

Suppose you need to undergo surgery or any X-ray or CT scan using a dye or contrast agent that needs to be injected into your veins. In that case, you may need to stop using Janumet XR temporarily. Ensure you inform your healthcare provider that you are using this medicine.

Strictly follow your doctor’s orders about using Janumet XR if you are pregnant or become pregnant. It is important to control diabetes during pregnancy, and if blood glucose level is high, complications may occur in both the mother and the baby.

Premenopausal women taking metformin may have an increased risk of unintended pregnancy because metformin may stimulate ovulation. Talk with your healthcare provider and ask about your risk.

Janumet XR side effects

Most medications, including Janumet XR, may cause unwanted side effects. Some may go away after some time or the body has already adjusted to the drug. While some may need to be reported or need immediate medical attention.

Here are the common side effects of using Janumet XR: 

-Nausea, vomiting, gas, indigestion, diarrhea, and upset stomach 



-Runny or stuffy nose, sneezing, and sore throat (cold symptoms) 

-Low blood sugar (hypoglycemia), when used together with sulfonylurea or insulin

Here are the serious side effects caused by Janumet XR: 

-Bullous pemphigoid 

-Low blood sugar level (Hypoglycemia) 

-Pancreatitis, inflammation of the pancreas 

-Severe joint pain 

-Lactic acidosis 

-Allergic reaction 

-Heart problems 

-Kidney problems 

If any of the above conditions or symptoms occur, seek medical help right away.

Janumet XR diarrhea

Janumet XR can usually cause gastric side effects such as upset stomach, gas, nausea, vomiting, and diarrhea.

How much does Janumet XR cost in Canada? 

Prescription Point offers affordable medications, including this drug. We also ensure safe and hassle-free transactions whenever you order your prescription from us.   

Check our prices at the top of this description and order yours today.

Frequently asked questions

Can Janumet XR be taken twice daily? 

Janumet XR is usually taken orally once daily, preferably in the evening. Taking this medication with food lowers gastrointestinal side effects associated with its metformin content.

What’s the Difference between Janumet and Janumet XR? 

Both medications are used together with diet and exercise to control blood sugar levels in people with type 2 diabetes. The only difference is how frequently they are taken in a day. 

Janumet is taken twice daily, whereas Janumet XR (extended-release) is taken once daily.

What are the alternatives to Janumet XR? 

Janumet XR is a combination of metformin hydrochloride extended-release and sitagliptin, so you can order them separately, or there is another diabetic medication that you can take but ensure you consult your doctor first before starting another medication for your safety.

Does Janumet XR cause weight loss? 

Janumet XR is not prescribed for weight loss, but its component, which is metformin, is sometimes prescribed off-label for weight loss. There is a possibility that you may lose weight while taking this medication.

How does Janumet XR work? 

Janumet XR consists of two antidiabetic medications with a harmonizing mechanism of action. One of them is sitagliptin, an orally-active dipeptidyl peptidase-4 (DPP4) inhibitor that works by increasing and prolonging active incretin levels.  

The other antidiabetic component is metformin hydrochloride extended-release, which works in three ways: reduces the amount of glucose the liver produces, reduces the amount of glucose the intestines absorb, and helps restore the body’s proper response to insulin. 


Additional information

Brand Name:

Janumet XR

Scientific Name:

Sitagliptin/Metformin HCI XR

Other Names:

Janumet XR


50/500mg, 50/1000mg, 100/1000mg

Quantities Available:

28, 56, 60, 84, 112, 120, 168, 180


Extended Release Tablet

The information above is provided by third parties to for Janumet XR (Sitagliptin/Metformin HCI XR). This information is for general purposes only and is not intended to replace a physician's advice. Always consult with your doctor or a qualified health care professional if you need advice on any medical concerns.